Cialis

Cialis (Tadalafil) for Treatment of ED

Introduction:
Cialis is the brand name for the drug Tadalafil acting as a PDE5 inhibitor. It is also marketed under the name Adcirca as a treatment for pulmonary arterial hypertension. It was originally developed by the biotech company in US, Icos Corporation. Since the company is now a part of Eli Lilly and company, the drug is manufactured and marketed by Lilly ICOS. ICOS is famed for its many pioneering work in the area of biotechnology. It has successfully developed many new drugs and many of them have successfully reached the stage of clinical trials.

However, Tadalafil has earned a name for the company as a drug is an effective treatment for erectile dysfunction. Though the drug was discovered by the pharmaceutical company Glaxo SmithKline, it was developed by ICOS.

Soon after its release a global advertisement campaign was run by Grey Worldwide agency and the results helped ICOS to make profits on the new drug.

But back in 1994 the scientists at Pfizer had made a discovery that Sildenafil which was found to have properties to inhibit PDE5 enzyme and instead of the heart medicine for which the drug was intended to be used got the recognition that it is a treatment for erectile dysfunction. Similarly ICOS were not testing the compound called IC351 for this condition but recognized its effect. It received a patent in 1994 itself for the compound IC351. After the clinical trials FDA approval was obtained.

Effectiveness and mechanism of action of Cialis:
All the drugs prescribed for ED like Viagra, Levitra and Cialis work by inhibiting the enzyme PDE5. But the distinction of Cialis is that it has much higher half life of almost eighteen hours compared to short half life of 4 to 5 hours of both Levitra and Viagra. So Cialis has longer duration of its effectiveness.

Sexual stimulation causes penile erection by increased blood flow mediated by the release of Nitric oxide at nerve tips and causes production of cGMP in smooth muscles. But the PDE 5 enhances the erectile functions by increasing the quantity of cGMP, Tadalafil inhibits this But it is to be noted that the stimulation is required for the release of NO, without sexual stimulation the drug has no effect.

Dosage:
It is recommended that men can take 10 mg drug every day. It may be increased up to 20 mg a day or can be even reduced to 5 mg per day. Lilly ICOS decided to check the effectiveness of a taking the drug of 5 mg once a day to avoid the inconvenience for the persons to plan meticulously the time for taking the drug to match is sexual program. European Commission has approved this plan of 25 to 5 mg drug to be taken once a day.

Side Effects:
A clinical trial on 15000 volunteers and usage by over 8 million people all over the world has given a reliable result of the possible side effects of Cialis. Commonly observed side effects have been indigestion, headache, muscle and back pain, and flushing. These are the natural results of the action of PDE5 inhibition and are found disappear in a short time. But for some persons having some risk factors like hypertension, diabetes, coronary heart disease showed the symptoms of vision impairment.

Price:
Cialis drug is priced at around 1.05 USD for 10 mg drug but there are offers from online stores with attractive prices for package deals.

Cialis (or Tadalafil) is a medication which works by increasing blood pressure to some partical parts of your body and relaxing muscles. Cialis is prescribed to men who treat their erectile dysfunction. The medication treats the symptoms of BPH (benign prostatic hyperplasia) – the condition of enlarged prostate gland, and also for all the purposes listed in the medication guide which goes with Cialis. Before start taking Cialis study the following instructions. You should go through complete medical examination in order to get aware if you have allergy to Cialis or any other nitrate drug such as nitroglycerin (Transderm Nitro, Nitro Dur, Nitrostat, Nitrolingual); isosorbide denitrate (Isochron, Isordil, Dilatrate), isosorbide mononitrate (ISMO, Imdur, Monoket) and “poppers”. After taking Cialis you may feel nauseated or dizzy during sexual interaction or even you can feel pain, tingling in your neck, jaw, arms or chest, have numbness stop the interaction and call the emergency. These symptoms may be side effects of Cialis and lead to serious complications. Take Cialis once a day and let a 24 hours-period pass between the doses. It may happen that your erection lasts for more than 4 hours and is very painful. In this case you must have emergent medical assistance as prolonged erection damages your penis. Cialis can also influence on the optic nerve by decreasing theblood to pressure so causing unexpected loss of vision. It is not a common problem, nevertheless it may happen with people who suffer from diabetes, hart disease, high cholesterol and high blood pressure, or pre-existing problems with eyes; people smoking and those who are older than 50 years. Don’t use Cialis without consulting a doctor and having the prescription.